Endocrine Abstracts

ObjectivePlant-derived extracts have long been used to treat Type 2 diabetes mellitus (T2DM), but their effects have not been rigorously investigated at the cellular level in vitro. The aims of the current study were to determine the effects of a virgin isolate of Gymnema sylvestre (GS), designated OSA, on pancreatic β-cell function.Materials and MethodsCell viability was measured by Trypan...

Objective: The extracellular calcium-sensing receptor (CaR) is expressed on many different cell types other than those involved in the systemic regulation of plasma calcium. We have demonstrated previously that insulin-producing beta cells express the CaR. In this study we have used a calcimimetic CaR agonist (A568) to investigate the effects of CaR activation on beta cell function.Methods: Experiments used the insulin secreting MIN6 cell line or isolate...